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USB 2.0 High-Speed (480Mbps) Switch with 5V Protection

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The PI3USB221E is a high-bandwidth switch specially designed for the switching of high-speed USB 2.0 signals in handset and consumer applications, such as cell phones, digital cameras, and notebooks with hubs or controllers with limited USB I/Os.

The wide bandwidth (1.1 GHz) of this switch allows signals to pass with minimum edge and phase distortion. The device multiplexes differential outputs from a USB host device to one of two corresponding outputs. The switch is bidirectional and offers little or no attenuation of the high-speed signals at the outputs.

It is designed for low bit-to-bit skew and high channel-to-channel noise isolation, and is compatible with various standards, such as high-speed USB 2.0 (480 Mbps).

The PI3USB221E offer over voltage protection for the D+/D- pins as per the USB 2.0 specification. With the chip power on or off if D+/D- pins are shorted to VBus (5V+/-5%), a less than 3.8V (typical) signal will transmit through 1D+/1D- and 2D+/2Doutput.


  • VDD Operation at 2.5V and 3.3V
  • VI/O Accepts Signals up to 5.5V
  • 1.8-V Compatible Control-Pin Inputs
  • Low-Power Mode When OE Is Disabled (2 µA)
  • rON = 6Ω Maximum
  • ΔrON = 0.2Ω Typical
  • Cio(on) = 4pF Typical
  • Support Over Voltage Protection
  • Low Power Consumption (50 µA Maximum)
  • ESD Performance
  • IO Pins
    • 12KV HBM
    • 1KV CDM
    • +/-8KV contact Discharge (IEC61000-4-2)
    • VDD, GND, S, OE Pins
    • 4KV HBM
    • 1KV CDM
  • High Bandwidth (1.6 GHz Typical)
  • Totally Lead-Free & Fully RoHS Compliant 
  • Halogen and Antimony Free. “Green” Device 
  • For automotive applications requiring specific change control (i.e. parts qualified to AEC-Q100/101/200, PPAP capable, and manufactured in IATF 16949 certified facilities), please contact us or your local Diodes representative. https://www.diodes.com/quality/product-definitions/
  • Packaging (Pb-free & Green):
    • 10-contact, UDFN (ZW10)
    • 10-contact, UQFN (ZUA10)


  • Routes Signals for USB 1.0, 1.1, and 2.0
  • Mobile Industry Processor Interface (MIPI) Signal Routing

Product Specifications

Product Parameters

Compliance(Only Automotive supports PPAP) Standard
Analog or Digital? Analog
Configuration 1 Differential Channel 2:1
Differential Channels 1
HotInsertion 0
Lanes 1
OtherFeatures N/A
RailToRail N/A
Signal Type Differential
Single Ended Channels No
Voltage 3.3

Technical Documents

Recommended Soldering Techniques


Additional Technical Documents are available upon request: 
Application information, Evaluation board, and Other technical documents

Request Documents
Orderable Part Number Status Package Environmental Compliance Packing Buy from Distributor /
Contact Sales
Request Samples
Qty. Carrier
PI3USB221EQ1ZUAEX Active U-QFN2015-10 TPGP 3000 T&R


Authorized Distributor Quantity Inventory Date Countries/Regions Buy Online
Farnell, An Avnet Company 2995 11/26/2022 England Buy Now
Request Sample
PI3USB221EZUAEX Active U-QFN2015-10 TPGP 3000 T&R


Authorized Distributor Quantity Inventory Date Countries/Regions Buy Online
Arrow Electronics 620 11/26/2022 United States Buy Now
Future Electronics - Asia 3000 11/25/2022 Singapore Contact Sales
Request Sample
PI3USB221EZWEX Active U-DFN3030-10 TPGP 3000 T&R


Authorized Distributor Quantity Inventory Date Countries/Regions Buy Online
Arrow Electronics 2575 11/26/2022 United States Buy Now
Mouser Electronics Inc. 2747 11/26/2022 South America, North America, Asia, Europe, Middle East Buy Now
Digi-Key Electronics 57913 11/25/2022 Europe, Asia, North America Buy Now
Request Sample
PI3USB221EZWEX-13R Active U-DFN3030-10 TPGP 3000 T&R Contact Sales Request Sample

Environmental Compliance Legend:
LFF: Pb-Free Finish and RoHS 5/6
TLFP: Totally Pb-Free Product and RoHS 6/6
LFGP: Pb-free Finish and Green Product, RoHS 5/6 and Halogen Free
TPGP: Totally Pb-Free and Green Product, RoHS 6/6 and Halogen Free
GREEN: Halogen-free and RoHS compliant
RoHS: RoHS compliant but NOT halogen-free

Product Change Notices (PCNs)

A PCN may only apply to specific orderable part numbers in this datasheet. Please refer to the corresponding PCN to see the exact orderable part number(s) affected.

PCN # Issue Date Implementation Date Subject
PCN-2510 2021-02-26 2021-05-26 Qualified Additional A/T Sites, Fab Site and Data Sheet Change